Document Type
Original Article
Abstract
Background: Esophageal Varices (EV) caused by liver cirrhosis is a very common complication where endoscopy is the best screening procedure. Insulin resistance (IR) is a reliable predictor of portal hypertension. Aim of the work: This study aims to compare and evaluate the role of markers of insulin resistance and other non-invasive markers in detection of EVs in patients with liver cirrhosis. Patients and Methods: fifty patients were screened in this cross-sectional study in the gastroenterology unit of internal medicine department by abdominal ultrasound. ELISA technique was used to estimate fating serum insulin levels. Furthermore, (HOMA-IR) referring to the Homeostasis model assessment of insulin resistance was carried out. Results: Cirrhotic patients whether they possessed any grade of EV or not correlated with higher insulin resistance with their platelet count/spleen diameter ratio (PC/SD) and spleen diameter showing a statistically significant difference among the groups. Conclusion: Elevations in insulin resistance (as they were assessed by HOMA-IR) were found to be good predictors of development of EVs non-invasively. Diameter of the Portal vein (PV), diameter of the spleen, and PC/SD were also found to be good predictors of EVs.
Keywords
Insulin Resistance; Esophageal Varices; Diabetes Mellitus
Subject Area
Internal Medicine
How to Cite This Article
Hasabo, Abdelhaleim Abdelghany; El Fatah, Mahmoud Osama Ahmed Abd; Yahia, Mohamed Basiouny; and Morsy, Gamal Zakaria Ali
(2023)
"The Role of Insulin Resistance in the Prediction of Esophageal Varices in Cirrhotic non-Diabetic patients,"
Al-Azhar International Medical Journal: Vol. 4:
Iss.
5, Article 6.
DOI: https://doi.org/10.58675/2682-339X.1833
