•  
  •  
 

Document Type

Original Article

Abstract

Background: Hepatitis B virus (HBV) infection may last for a long time and eventually result in liver cirrhosis and hepatocellular cancer (HCC). The best approach for managing HBV infection is primary prevention through vaccination strategies. Anti-HBs concentrations may fall sharply within the first year following the primary HBV immunisation, and fall more slowly after that. The relationship between insulin resistance and Anti-HBs persistence, particularly in a non-diabetic population, has not been examined in any Egyptian studies. Aim of the work: In this study, healthy non-diabetic Egyptian participants who received hepatitis B vaccines were examined to determine the relation between insulin resistance & the level of anti-HBs (post vaccination).

Patients and method: There were four groups, 25 participants per each one of them. Groups A (had insulin resistance) and B (had no insulin resistance), were born after 1992 (the year that compulsory baby vaccinations were introduced in Egypt), while groups C (had insulin resistance) and D (had no insulin resistance) were born before 1992. Hepatitis B vaccination (3- dose series on a 0-1- 6-month) was administered to these groups (C and D). One to four months following the initial course of three immunization doses, HBs antibody level was determined. Each participant received evaluations for metabolic syndrome, insulin resistance, and obesity.

Results: P value of anti-HBs of studied groups A & B was 0.04 and for groups C & D were 0.001. There was one patient of group A, anti-HBs less than 10. P value of fasting insulin of studied groups A & B was 0.001 and groups C & D was 0.001.There is inverse correlation between HBs- Abs titer & HOMA IR and Insulin level.

Conclusion: In seemingly healthy Egyptian, non-diabetic men and women, inadvertent loss of anti-HBs over time was correlated with insulin resistance.

Keywords

Insulin Resistance; anti-HBs; non-diabetic healthy adults

Download

Share

COinS