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Corresponding Author

Ragab El-Saed El-Dibany

Document Type

Original Article

Abstract

Objectives: Our objective is to assess H. pylori infection in chronic hepatitis C Egyptian patients and its hepatic impact.

Background: Helicobacter pylori lives mainly on gastric mucosa and is one of the common infections worldwide.

In liver cirrhosis it may lead to impaired liver functions due to fibrosis in chronic liver diseases as HCV.

Patients and Methods: This was a cross sectional prospective study included 40 of HCV infection and 20 health subjects as a control. It was conducted on in the Al-Azhar University Hospitals during the period from 1st Feb 2020 to 30th Sept 2021.

After approval of local ethics committee, all patients included in the study were informed about the procedure before starting.

Patients were subjected to complete history and clinical examination; complete investigations needed and endoscopic examination.

Results: Our study revealed a non-significance for age, gender, BMI, with predominance antidiabetic drug use. There was significant increase in WBCs, Hb decrease, decrease platelets, ESR. In addition there was a elevations in liver functions, total and direct bilirubin with significant reduction in serum albumin. Also, a significant elevation in triglycerides, LDL and HDL without significant change in cholesterol level was present.

HCV infection present significantly whether by ELISA or qualitative PCR and H. Pylori also present significantly with significant elevation of -FP in our cases. U/S revealed significant presence of cirrhotic changes with or without splenomegally.

Conclusion: From our study we can concluded a positive association between H. pylori infection and chronic hepatitis C and the resulting cirrhosis.

Keywords

CLD, Chronic liver disease; HP, Helicobacter Pylori; LC, liver cirrhosis

Subject Area

Endemic diseases and tropical medicine, Internal Medicine, Public health

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