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Corresponding Author

Therese Sobhy Ghatas

Document Type

Original Article

Abstract

Introduction: There has been rising attention in the evaluation of procalcitonin, and C-reactive protein serum levels for predicting treatment efficacy of patients who hospitalized for community acquired pneumonia. Methods: Taken of blood samples for measurement of (CRP) and (PCT), on the day of admittance (PCT-D1; and CRP-D1), within (48 to72) hours after the admittance (PCT-D3; and CRP-D3), also in 144 to192 hours next to admission. CURB 65 in adding to the (Pneumonia Severity Index) were evaluated on the day of admittance. Results: 112 hospitalized patients with CAP were involved in the work. Failure of treatment was recognized in 30 individuals (26. 7%). Patients experienced early treatment failure displayed highly significant results of; PCT D1, D3, and CRP D3, PCT D3/D1 ratio, and CRP D3 / D1 ratio than in those whose treatment was successful. CRP D1 values were similar in both groups. Patients experienced late treatment failure displayed highly significant elevated values of PCT3, PCT D3 / D1, PCT D7, PCT D7 / D1, CRP D3, CRP D3 / D1, CRP D7, and CRP D7/D1 than in patients who had treatment success. The PCT D1 values augmented with elevating severity of pneumonia. Nevertheless, the results of (CRP-D1) were not. Conclusions: (PCT) should be defined sequentially not on admittance alone to expect the therapy outcome in hospitalized community acquired pneumonia patients.

Keywords

C reactive protein; Pneumonia; Procalcitonin; Treatment.

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