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Corresponding Author

Emad Hamdi Ahmed Ali

Document Type

Original Article

Abstract

Background: When end-stage renal disease (ESRD) patients are getting dialysis, thyroid dysfunction is a prevalent but poorly understood endocrine illness

Aim of the work: To assess the pattern of thyroid profile, that is, Triiodothyronine (FT3), free thyroxin (FT4), and thyroid stimulating hormone (TSH) in serum-free among individuals with advanced chronic renal disease (CRD) who are doing hemodialysis or not.

Patients and methods: This study is a prospective observational study that included 60 patients with chronic renal disease, as well as 30 control cases that were matched in terms of sex and age. All participants were recruited from the outpatient and inpatient internal Medicine and Nephrology Departments at Sayed Galal Al-Azhar University Hospital.

Results: It was not statistically significant to find differences in age or sex across the groups; nevertheless, differences in urea or creatinine were significant, and differences in Hb were significant; and liver enzymes (serum transaminases) and serum phosphorus significantly differed between the groups (diseased patients and control group). Regarding the thyroid profile, there were notable disparities between the groups because there were more hypothyroid individuals among the sick patients— more so than in the healthy subjects—especially those with end-stage renal failure.

Conclusion: ESRD patients frequently have thyroid dysfunction, with hypothyroidism being the most common thyroid condition, especially if they are receiving regular hemodialysis. Even if a patient is euthyroid, hypothyroid symptoms are frequently seen in it. The overlap in symptoms between ESRD and hypothyroidism makes the diagnosis of hypothyroidism challenging and could be overlooked in the ESRD population.

Keywords

Thyroid function; Chronic Renal Disease; Dialysis

Subject Area

Clinical Pathology

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