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Corresponding Author

Mohamed Mohamed Saad

Document Type

Original Article

Abstract

Background: Laparoscopic cholecystectomy (LC) has surpassed open surgery as the preferred form of cholecystectomy care due to its minimally invasive nature, low level of patient arousal, and rapid healing rate.

Objectives: This research aimed to determine whether patients undergoing LC utilized postoperative analgesics.

Methods: A prospective, randomized, controlled study was initiated with a sample size of 125 patients undergoing elective LC. These patients were aged between 21 and 45 and were of both sexes. A bolus of subanesthetic ketamine (0.2 mg/kg) was administered to patients in the Infusion group at the following rates: 0.2 mg/kg two minutes prior to the surgical procedure, 0.2 mg/kg after induction, and 0.1 mg/kg/h continuously.

Results: The bolus and control groups were significantly lower in times to first rescue analgesia (P <0.001). Significantly higher total morphine consumption was observed in the bolus and control groups compared to the infusion group (P <0.001). At 2h, 3h, 4h, 5h, and 6h, the infusion group demonstrated a statistically significant reduction in the visual analog scale (VAS) in comparison to the control and preload groups (P <0.05). Significantly higher Ramsay sedation scores (RSS) were observed at 0h in the control infusion than in the bolus groups. Infusion and bolus constituents reported considerably higher levels of satisfaction in comparison to the control group (P<0.05).

Conclusions: Ketamine decreased postoperative morphine consumptions and VAS pain score with more hemodynamic stability and postoperative sedation than subanesthetic ketamine bolus 0.2mg/kg after induction of general anesthesia and saline received patients, but ketamine bolus only is superior to saline received patients.

Keywords

Ketamine; Postoperative Pain; Laparoscopic; Cholecystectomy

Subject Area

Anesthesiology

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