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Corresponding Author

Hani Ismail Hamed Abu Khalil

Document Type

Original Article

Abstract

Background: Chronic kidney disease (CKD) is frequently complicated by anemia & mineral bone disorders.

Aim and objectives: To evaluate the connection between anemia & markers of calcium metabolism in stages 3-5 CKD nondialysis-dependent on dialysis individuals.

Subjects and methods: A sample of sixty patients participated in the current investigation, all of whom had CKD on conservative treatment. All understudied patients were submitted to full medical history taking, apparent clinical examination, and laboratory investigations, including full blood picture, total serum calcium, serum phosphorus, Parathormone hormone (PTH), and total 25-OH Vitamin D.

Results: A statistically significant correlation between hemoglobin concentration (Hb) and serum total calcium (Ca) was found in the current investigation. Hemoglobin levels decrease with decreasing calcium levels. The study's key statistical findings include the connection between CKD patients' low hemoglobin and high blood phosphate (PO4) levels. Our research supported other studies that demonstrate a strong correlation between low hemoglobin levels in CKD patients and vitamin D insufficiency. Additionally, it showed that in CKD patients, serum parathormone (iPTH) and hemoglobin level were inversely correlated. Any time there is a rise in serum PTH, there is a corresponding drop in hemoglobin levels. Hemoglobin & eGFR have a statistically significant association in the current investigation (p-value = 0.005) (r = 0.36).

Conclusion: Correcting renal osteodystrophy is thought to be a therapeutic target for anemia, since we reported finding a correlation between blood bone metabolic indicators & anemia in individuals CKD.

Keywords

Haemoglobin; Mineral bone disorders ; Glomerular filtration rate

Subject Area

Internal Medicine

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