Document Type
Original Article
Abstract
Background: Systemic Lupus Erythematosus (SLE) is an autoimmune disease that affects many systems, characterized by an inflammatory process induced by an immune- complex formed by autoantibodies and autoantigens.
Aim: To detect the effect of Supplementation with vitamin D on fatigue degree & activity in SLE disease patients with vitamin D deficiency.
Patients and methods: This randomized controlled research was carried out on 100 female cases of SLE & vitamin D deficiency in Al-Azhar University Hospital (Assuit) from January 2019 to November 2021. Patients were randomized into two groups.
Results: The SELDAI and FSS scores after 3 months of follow-up presented a statistically significant variance among both groups (P-value<0.05). After following up, an inverse non-statistically significant correlation between vitamin D level & disease activity (SLEDAI) in both groups (P-value= 0.117, r= -0.204 in the intervention group), (P-value=0.223, r= -0.197 in the control group) was detected.
Conclusion: The overall FSS value was enhanced in the current study with vitamin D supplementation. Therefore, correction of vitamin D insufficiency may be critical for reducing fatigue symptoms and improving overall health in SLE patients.
Keywords
SLE; Vitamin D; FSS; SELDAI
Subject Area
Internal Medicine
How to Cite This Article
Sloma, Abdel Rahman G.; Abdelkareem, Mohamed Ismail Mohamed; Hashim, Alaa Mohamed; and Azeem, Haitham A.
(2024)
"Effect of Vitamin D Supplementation on Disease Activity and Fatigue In Systemic Lupus Erythematosis Patients with Hypovitaminosis D: A Randomized Controlled Trial,"
Al-Azhar International Medical Journal: Vol. 5:
Iss.
8, Article 46.
DOI: https://doi.org/10.58675/2682-339X.2622
