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Corresponding Author

Mahmoud Ahmed Ebrahim

Document Type

Original Article

Abstract

Background: Intestinal anastomosis is a prevalent surgical operation that is performed both electively and in emergency situations. Anastomotic leakage is a catastrophic complication that occasionally arises after intestinal anastomosis (AL).

Purpose: To evaluate early AL detection using biochemical markers (total leukocyte count (TLC), Procalcitonin (PCT), lactic dehydrogenase (LDH), and C-reactive protein (CRP)) for AL presence or absence.

Patients and methods: Forty patients (16 years of age or older) who underwent elective open or laparoscopic gastrointestinal surgery with primary anastomosis were included in this prospective study. TLC, CRP, PCT, and LDH were measured in all patients. The levels of CRP, PCT, and LDH were assessed 8 hours following the incision, on the third and fifth days postoperatively, and daily if parameters were elevated until they returned to normal, and the patient was released.

Results: Regarding the correlation between TLC, CRP, PCT, LDH, and the presence of leakage, a significant difference was reported regarding elevated TLC, CRP, PCT, and LDH with the presence of leakage.

Conclusions: Monitoring levels of CRP, PCT, LDH, and white blood cell trends may have predictive value for detecting AL early after GI procedures with reestablished intestinal continuity.

Keywords

Anastomotic Leakage; Intestinal anastomosis; Gastrointestinal Surgery

Subject Area

General Surgery

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