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Corresponding Author

Ahmed Bassiouny Saied Ahmed Allam

Document Type

Original Article

Abstract

Background: Chronic Kidney Disease (CKD) is a prevalent global health burden often associated with increased cardiovascular complications and mortality.

Aim and objectives: The aim of this study is to investigate the impact of Hemodiafiltration (HDF) on Beta-2 Microglobulin (B2M) levels in regular hemodialysis patients and to evaluate the effectiveness of hemodiafiltration in reducing B2M accumulation in these patients.

Subjects and methods: This study is a prospective study conducted at the Nephrology Unit of Bab El-Shaareya (Sayed Galal) University Hospital. It includes 80 patients with chronic renal failure who are receiving hemodialysis treatment. The patients will be age and sex-matched to ensure comparability between groups.

Result: Our results revealed significant improvement in renal function parameters, manifested by a substantial reduction in blood urea nitrogen levels and enhancements in glomerular filtration rates in patients undergoing HDF treatment. Furthermore, extensive analysis of cardiac function parameters unveiled noticeable improvements in left ventricular ejection fraction and reductions in cardiac dimensions and valve abnormalities after 12 months of HDF therapy.

Conclusion: B2M serves as a valuable marker of renal function and cardiovascular risk in patients with advanced CKD. The reduction in serum B2M levels following HDF treatment reflects the therapy's efficacy in improving renal function and mitigating cardiovascular risk, thus highlighting the potential of HDF as a comprehensive therapeutic approach for individuals with cardiorenal complications.

Keywords

Hemodiafiltration; Beta-2 Microglobulin; Regular Hemodialysis; Impact

Subject Area

Plastic surgery

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