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Corresponding Author

Department of Internal Medicine and Nephrology, Faculty of Medicine for boys, Al-Azhar University, Cairo, Egypt

Document Type

Original Article

Abstract

Background: Maintenance hemodialysis (HD) is a significant global treatment for end-stage renal disease patients.

Aim: To assess the role of hemodiafiltration versus hemodialysis on anemia profile among regular hemodialysis cases.

Patients, and methods. This cross-sectional observational research was performed on forty patients randomly separated into two groups: Group A: 20 patients on hemodialysis (HD) modality with hemoglobin < 10 gm/dl to be shifted to hemodiafiltration (HDF) and Group B: 20 patients on HDF modality at nephrology unit Bab El-Sharia, AL Azhar University Hospital.

Results: There was a significant increase in hemoglobin (Hb) and hematocrit (HCT) levels in Group B at the 6-month follow-up (p=0.039 and p=0.029, respectively). No significant variations were observed in other parameters, such as red blood cell (RBC) count, white blood cell (WBC) count, and platelet levels. No significant distinctions were found in serum iron, transferrin saturation (TSAT), serum ferritin, serum albumin, serum potassium (K), total iron-binding capacity (TIBC), alanine transaminase (Alt), and bilirubin at any time point. However, a notable increase in serum sodium (Na) was observed in Group B at the 3-month (p=0.045*) and 6-month (p=0.038*) follow-up.

Conclusion: Transitioning from HD to HDF didn't significantly impact the duration of the dialysis session. However, HDF showed superior efficacy in improving hematologic parameters, particularly hemoglobin and hematocrit levels, over a 6-month follow-up period. It also improved serum sodium levels, suggesting enhanced electrolyte balance. These findings suggest HDF may offer advantages in managing anemia and controlling electrolytes in hemodialysis patients with anemia.

Keywords

HD, HDF, Anemia

Subject Area

Internal Medicine

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