Glycated Hemoglobin as Predictor of Organ Dysfunction in Patients with Sepsis

Authors

Mohammed Essam Eldeen Mohammed Mohammed Hassan, Department of Internal Medicine, Faculty of Medicine for Boys, Al-Azhar University, Cairo, EgyptFollow
Ahmed Mohamed Abohassan, Department of Internal Medicine, Faculty of Medicine for Boys, Al-Azhar University, Cairo, Egypt
Atef Aboelfetouh Ibrahim, Department of Internal Medicine, Faculty of Medicine for Boys, Al-Azhar University, Cairo, Egypt
Mahmud Abdellatif Hashish, Department of Clinical Pathology, Faculty of Medicine for Boys, Al-Azhar University, Cairo, Egypt

Corresponding Author

Mohammed Essam Eldeen Mohammed Mohammed Hassan

Document Type

Original Article

Abstract

Background: Diagnosis of Sequential Organ Failure Assessment (SOFA) and also quick SOFA (qSOFA) scores, moving away from the SIRS criteria. Lastly, glycated hemoglobin (HbA1c) levels serve as a measure of average blood glucose above the previous three months and are not influenced by acute illness, making it a stable marker for assessing pre-existing hyperglycemia.

Methods: An observational research that was conducted retrospectively on a group of patients whose HbA1c level was determined upon ICU admission was conducted. At the Sahel Teaching Hospital, 100 patients were involved in the research. Patients were separated into two groups: a control group of 20 healthy individuals and a case group of 100 patients. Every patient underwent a thorough history taking, including clinical and laboratory assessments and SOFA and APACHE scores were calculated.

Results: A significant positive connection was observed between HbA1c and HR, blood glucose, serum creatinine, urea, CRP, APACHE II, SOFA score at admission, length of hospital stay, level of organ dysfunction, and ICU stay. There was a significant negative connection between HbA1c and PLT and WBCs. HbA1c can significantly anticipate organ failure in sepsis patients at AUC of 0.978, P value of <0.001, and at cut off value >6 %, with 100 % sensitivity, 94.94 % specificity, 91.1 % PPV and 100 %NPV. HbA1c was the only significant predictor of the severity of organ malfunction in sepsis patients.

Conclusion: Glycated hemoglobin (HbA1c) levels at ICU admission are a significant predictor of death and the evolution of organ malfunction in sepsis patients.

Keywords

Glycated Hemoglobin; Organ Dysfunction; Sepsis

Subject Area

Internal Medicine

How to Cite This Article

Hassan, Mohammed Essam Eldeen Mohammed Mohammed; Abohassan, Ahmed Mohamed; Ibrahim, Atef Aboelfetouh; and Hashish, Mahmud Abdellatif (2024) "Glycated Hemoglobin as Predictor of Organ Dysfunction in Patients with Sepsis," Al-Azhar International Medical Journal: Vol. 5: Iss. 8, Article 24.
DOI: https://doi.org/10.58675/2682-339X.2600