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Corresponding Author

Mahmoud Ali Mohamed Mohamed

Document Type

Original Article

Abstract

Background: The cause of ventricular arrhythmias and sudden cardiac mortality in patients with MVP is not completely known.

Aim: To investigate the significance of assessing mitral annular disjunction using echocardiography in patients with mitral valve prolapse (MVP) and its impact on arrhythmias as evaluated by Holter monitoring. Additionally, to determine specific clinical and echocardiographic parameters that can predict the development of arrhythmias in MVP patients.

Methods: Seventy consecutive individuals with an MVP diagnosis were enrolled in our cross-sectional investigation. Using 2D echocardiography, patients were categorized into the following groups based on whether they met the MAD criteria: There were 50 mitral annular disjunction (MAD) patients in Group A and 20 non-MAD patients in Group B.

Results: A strong positive correlation between the degree of disjunction and the presence of arrhythmia, and the burden of PVCs. The AUC of 0.765±0.073, statistically significant P value of 0.001, sensitivity of 81%, specificity of 65%, and PLAX view cut-off disjunction distance of 9.8 mm. With an AUC of 0.655±0.079, a statistically insignificant P value of 0.056, and a sensitivity and specificity of 69% and 76%, respectively, a 10.1 mm cut-off disjunction distance in the AP4 presentation. AUC of 0.755±0.078 and statistical significance are achieved with a 10.2 mm cut-off overall disjunction distance, which yields 76% sensitivity and 70% specificity.

Conclusions: When considering the degree of disjunction, there was a statistically significant positive association between the PVC burden and disjunction degree.

Keywords

Echocardiography; Mitral Valve Prolapse; Mitral Annular Disjunction

Subject Area

Cardiovascular

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