Comparative study about the use of Metformin Versus Progesterone as a treatment in cases of Simple Endometrial Hyperplasia without atypia

Authors

Al-Shimaa Alam Abdel Latef, Department of Obstetrics and Gynecology, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt
Faiza Ahmed Abdel Hakam, Department of Obstetrics and Gynecology, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt
Samah Mohamed Attia, Department of Clinical Pathology, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt
Amira Abdelsalam Meghawry Shamia, Department of Obstetrics and Gynecology, Faculty of Medicine for Girls, Al-Azhar University, Cairo, EgyptFollow

Corresponding Author

Amira Abdelsalam Meghawry Shamia

Document Type

Original Article

Abstract

Background: In endometrial hyperplasia (EH), the tissue of the endometrium is stimulated estrogenically without progesterone's counterbalancing behaviors, leading to an abnormal growth of endometrial glands. Metformin, a biguanide, is used widely as a first-line pharmacological treatment in cases with type 2 diabetes.

Aim and Objectives: To compare the metformin effects & progesterone on simple endometrial hyperplasia without atypia in order to determine if Metformin is clinically efficient in these conditions.

Patients and methods: This is a cohort prospective research that included a total of (60) women who have perimenopausal bleeding with histopathologically confirmed simple endometrial hyperplasia without atypia by D&C at the Department of Gynecology & obstetrics at Al-Zahra University Hospital Al Azhar university hospital from January 2022 to July 2023. All cases were split into two equal groups (thirty cases each): progesterone group (A) received progesterone 10mg twice per day for three months. Metformin group (B) received metformin 500mg twice per day for three months.

Results: There is no statistical significance between both groups in relation to age, parity, BMI, medical diseases, abortion, previous CS, and endometrial thickness before treatment. There is a statistical significance among group A (progesterone) & group B (Metformin), rendering to bleeding time, clinical improvement after treatment, pathological changes after treatment, and success rate after treatment.

Conclusion: Metformin and progesterone were effective & safe in the cure of endometrial hyperplasia without atypia.

Subject Area

Obstetrics and Gynecology

How to Cite This Article

Abdel Latef, Al-Shimaa Alam; Abdel Hakam, Faiza Ahmed; Attia, Samah Mohamed; and Shamia, Amira Abdelsalam Meghawry (2024) "Comparative study about the use of Metformin Versus Progesterone as a treatment in cases of Simple Endometrial Hyperplasia without atypia," Al-Azhar International Medical Journal: Vol. 5: Iss. 8, Article 13.
DOI: https://doi.org/10.58675/2682-339X.2589