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Corresponding Author

Mahmoud Adel Mohamed Ahmed Ghoneim

Document Type

Original Article

Abstract

Background: Diabetic nephropathy (DN) is a prevalent consequence of diabetes as well as the primary factor contributing to the development of chronic kidney disease. It is a degenerative condition characterized by the gradual deterioration of kidney function over time, ultimately resulting in end-stage renal disease (ESRD).

Aim and objectives: To examine the function of Urine E cadherin as an indicator for the early identification of diabetic nephropathy.

Patients and methods: This prospective trial was done on 100 persons admitted to the Nephrology outpatients for diabetic nephropathy at Damanhur Teaching Hospital. Based on the Diabetic nephropathy (DN) stage, the patients were separated into four groups: Stage 1 DN group included 24 cases, the Stage 2 DN group included 27 cases, the Stage 3 DN group included 25 cases, and Stage 4 DN group included 24 cases.

Results: There was statistically significant variance amongst the participated groups Regarding Urinary sE-cadherin/Cr (mg/l), glycated hemoglobin & serum creatinine (p<0.05) while there was no statistically significant change amongst the studied groups as regard duration also type of diabetes, diastolic blood pressure (DBP), systolic blood pressure (SBP), heart rate, temperature, fasting glucose, respiratory rate, urine albumin‐to‐creatinine ratio (UACR), albuminuria, glycated hemoglobin, glomerular filtration rate (GFR) blood urea nitrogen (BUN), & urine creatinine (p>0.05).

Conclusion: The present investigation establishes E-cadherin as a newfound indicator for diabetic nephropathy, which might be employed to ascertain the progression of DN. Consequently, evaluating the levels of E-cadherin in diabetic individuals could potentially have a significant effect on decelerating or possibly preventing end-stage renal disease.

Keywords

Urinary cadherin E; Diabetic nephropathy; ESRD

Subject Area

Internal Medicine

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