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Corresponding Author

Mohammed Shehata Shaban Shaban

Document Type

Original Article

Abstract

Background: Platelet breakdown and manufacturing issues are at the heart of immune thrombocytopenia, an autoimmune bleeding condition. Clinical features and laboratory tests performed after ruling out other disorders that cause thrombocytopenia are essential for making a diagnosis. In recent years, the pro-inflammatory cytokine interleukin 17 (IL-17) has been linked to autoimmune disease development.

Aim and objectives: To evaluate the Prognostic Value of IL-17 in persons with various categories of immune thrombocytopenic Purpura.

Subjects and methods: The current prospective trial included 90 patients with immune thrombocytopenia purpura who attended the haematology unit, internal medicine department, faculty of medicine, Al Hussein Hospital, and Al-Azhar University.

Results: There was a statistically significant alteration amongst the examined groups (Evaluation among studied groups according to interleukin 17) and HB in Complete blood count. There was a significant connection between IL-17 and Age and Lymphadenopathy. There was a significant connection between HB and Age, Lymphadenopathy, and Lymphadenopathy. There was a significant association between Platelets and Lymphadenopathy, Age, and Lymphadenopathy.

Conclusion: Egyptian children with Immune thrombocytopenic Purpura (ITP) have higher than average serum IL-17, suggesting a link between the two. Since blood IL-17 levels can predict the natural course of ITP and offer fresh insights into the pathophysiology of juvenile ITP, it may be useful to include it in the regular workup of children with Immune thrombocytopenic Purpura at the time of initial diagnosis.

Keywords

Interleukin 17; Thrombocytopenic Purpura; Auto Immune

Subject Area

Internal Medicine

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