Document Type
Original Article
Abstract
Background: Lupus nephritis (LN) is one of the most severe conditions associated with systemic lupus erythematosus (SLE). Interleukin-17 is one of the main inflammatory cytokines linked to LN, but the relationship is unclear.
Aim of the work: Examine the correlation between the histopathological findings, therapy response, and IL-17 serum level in cases with active LN and following pulse therapy.
Patients and methods: The current research divided 60 subjects into active LN, inactive LN, and control groups. Every individual underwent comprehensive history taking, a comprehensive physical examination, an evaluation of disease activity using the SLE disease activity index (SLEDAI), and clinical tests (including serum IL-17 levels). After the induction therapy, cases with active LN were followed up to determine the fate after treatment and to determine changes in the laboratory and urinary tested parameters.
Results: Compared to the inactive LN and control groups, the active LN group had statistically significantly higher IL-17 levels. The IL-17 level in the active LN showed a statistically significant decrease after treatment compared to before treatment.
Conclusion: In cases of SLE, a higher serum IL-17 level may help predict the level of LN activity. Active LN patients' serum IL-17 levels are predictive of treatment efficacy.
Keywords
SLE; LN; IL-17; Remission; Steroids
Subject Area
Internal Medicine
How to Cite This Article
Eid, Eslam Mohamed Diaa Abdel Khaleq; Farag, Farag Khalil; Gaber, Hassan Abdel Aziz; and Rafat, Mohamed Nabil
(2024)
"Impact of Pulse Steroid on the Level of IL-17 in Active Lupus Nephritis,"
Al-Azhar International Medical Journal: Vol. 5:
Iss.
7, Article 21.
DOI: https://doi.org/10.58675/2682-339X.2539
