Document Type
Original Article
Abstract
Background: One crucial element in the progression of rheumatoid arthritis (RA) is the cytokine tumor necrosis factor-α (TNF-α).
Objectives: To compare the pre- and post-biological treatment left ventricular (LV) systolic performance in a group of patients with active RA by global longitudinal strain (GLS), a marker of myocardial deformation.
Methods: This prospective trial involved 50 patients with active RA. Erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), Electrocardiogram (ECG), two-dimensional (2D)echocardiography, and 2D speckle tracking echocardiography were assessed.
Results: There was a positive correlation between GLS average length and ejection fraction (EF), fractional shortening (FS), apical 2-chamber view (A2), apical 3-chamber view (A3), and apical 4-chamber view (A4)) post-treatment (P
Conclusion: Treatment with anti-TNF-α does not substantially impact global LV systolic function assessed by GLS in a cohort of active RA patients, indicating that these medications have a protective effect. There was no difference in GLS before or after therapy with anti-TNF-α.
Keywords
LV Dysfunction; Active RA; Biological Treatment; Two-Dimensional Speckle Tracking Echocardiography; ECG
Subject Area
Cardiology
How to Cite This Article
Ibrahiem, Ahmed Zakaria; Mohammed, Yasser Radwan; Abd El-Hamid, Abd El-Hamid Ismael; and Ghit, Mohamed Magdy
(2024)
"Detection of Subclinical Left Ventricular Dysfunction in Active Rheumatoid Arthritis during Biological Treatment by Two-Dimensional Speckle Tracking Echocardiography,"
Al-Azhar International Medical Journal: Vol. 5:
Iss.
6, Article 48.
DOI: https://doi.org/10.58675/2682-339X.2508
