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Corresponding Author

Haitham Mohamed Abdullatif

Document Type

Original Article

Abstract

Background: Multiple sclerosis (MS) is a persistent autoimmune disorder affecting the central nervous system (CNS), characterized by inflammation, loss of myelin, as well as damage to nerve fibres, resulting in a range of neurological symptoms and different degrees of clinical impairment.

Aim and objectives: To detect if there is a relationship between Multiple sclerosis activity and Neutrophil/Lymphocyte Ratio.

Patients and methods: This prospective trial was done on 100 persons with MS patients (either known as Multiple sclerosis or newly diagnosed) presented to the neurology department and Multiple sclerosis unit of Al-Azhar university hospitals during relapse. The duration of the recruiting period was 6 months.

Results: The mean Neutrophil-lymphocyte ratio was 3.17±0.85 and 1.87±0.41 in patients before and after steroid therapy, respectively. Data showed significant differences between groups in NLR. A significant positive association was discovered among MS activity and NLR in addition to between NLR and C-reactive protein (CRP), secondary progressive multiple sclerosis (SPMS), relapsing remittent multiple sclerosis (RRMS), and primary progressive multiple sclerosis (PPMS). NLR showed 67% sensitivity and 82 % specificity. CRP showed 58% sensitivity and 70% specificity. Erythrocyte sedimentation rate (ESR) showed 62% sensitivity and 65 % specificity.

Conclusion: The presence of NLR revealed a strong correlation with both the level of disability activity in individuals with Multiple sclerosis. Our findings indicate that NLR can be used as a straightforward, quick, and cost-effective indicator of inflammation in relation to disability and activity in Multiple sclerosis. An increased NLR is linked to Multiple sclerosis; hence, studying the involvement of neutrophils in people with Multiple sclerosis could offer fresh perspectives on the development of Multiple sclerosis.

Keywords

Multiple sclerosis; Neutrophil/Lymphocyte Ratio; Expanded Disability Status Scale

Subject Area

Neurology

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