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Corresponding Author

AbdelFattah ElSaid Ahmed Eldihy

Document Type

Original Article

Abstract

Background: Preterm birth is defined as the delivery of a baby prior to thirty-seven weeks of gestation or less than 259 days following the first day of the woman's last menstrual period (LMP). Prematurity is a significant contributor to both neonatal deaths and health issues, as it is associated with long-term problems.

Aim and objectives: To evaluate the impact of vaginal progesterone compared to a placebo in preventing spontaneous preterm delivery in twin pregnancies.

Patients and methods: In this randomized, placebo-controlled study, which involved 120 patients and ran from the beginning of March 2023 to early December 2023, women with unchecked twin pregnancies at Al-Hussien Hospital A comparison was made between the administration of vaginal progesterone (four hundred mg per day) and a placebo, starting from weeks 11-14 to thirty-four weeks of gestation. Two groups of patients were formed: Group A comprised 60 cases whereby pregnant twin women were Administered a daily dosage of four hundred milligrams of vaginal progesterone.

Results: The two study groups did not significantly differ in terms of age, BMI, parity, twin type, laboratory characteristics, or cervical length. Group A had a higher frequency of spontaneous births between 28 and 34 weeks and between 34 and 37 weeks than group B. However, there was no statistically significant difference. Although there was no statistically significant difference, group A experienced somewhat more outcomes and problems than group B.

Conclusion: This study concludes that vaginal progesterone had no effect in preventing unplanned preterm delivery in twin pregnancies.

Keywords

Early vaginal progesterone; Twin pregnancies; Spontaneous pre-term birth

Subject Area

Obstetrics and Gynecology

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