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Corresponding Author

Shaymaa Mamdouh Eisa

Document Type

Original Article

Abstract

Background: Patients in need of intensive care due to acute kidney injury (AKI), a sudden decline in renal function commonly caused by severe clinical illness such as sepsis, it is common practice to employ acute-phase markers for systemic inflammation in clinical practice.

Aim and objectives: In critically ill patients, the relationship between AKI and neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and C3 and C4 levels should be examined.

Subjects and methods: The study, a case-control design, involved 80 patients of both sexes divided into two groups and was conducted by researchers from Al-Azhar University's Faculty of Medicine for Women.

Results: Regarding platelets, there were no statistically significant differences among the groups. More TLC and neutrophils were seen in Groups 2 and 3 compared to Group I and the control group. Even though groups 2 and 3 had significantly more lymphocytes than the control and group I did, the differences were not statistically significant. The control group had the lowest creatinine levels, followed by groups two and I, and then group 3. Group 3 had the highest urea levels, followed by groups 2 and I, and finally, the control group.

Conclusion: Both NLR and PLR show potential as low-cost, clinically relevant markers of activity and severity in the critically ill with acute kidney injury. It is crucial to note that NLR is not the only risk factor for renal prognosis in individuals with AKI and that it has only a modest impact on some key renal functions.

Keywords

Acute Kidney Injury; Platelet-To-Lymphocyte Ratio; Neutrophil-To-Lymphocyte Ratio; Prognosis

Subject Area

Internal Medicine

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