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Corresponding Author

Ismail Atia Khalil Elfauomy

Document Type

Original Article

Abstract

Background: Polycystic Ovary Syndrome (PCOS) is marked by hyperandrogenism, anovulation with menstrual irregularities, and morphologic polycystic ovarian alterations. The implicated hormonal abnormalities may extend to other endocrine glands.

Aim of the Work: To investigate whether thyroid hormone abnormalities and PCOS are related in Egyptian women.

Patients and Methods: There were 500 women in the cohort diagnosed with PCOS based on the 2003 Rotterdam Criteria. Clinical, menstrual, and reproductive factors and ovarian morphology were analyzed in relation to the underlying thyroid gland's clinical and hormonal status.

Results: The prevalence of amenorrhea, oligomenorrhea, and hirsutism/acne was found to be 16.2%, 54.8%, and 70.6%, respectively, with a mean Ferriman-Gallwey hirsutism score of 8.04 ± 4.101. Elevated Body Mass Index (30.40 ± 11.98 kg/m2) and waist circumference (91.77 ± 9.93 cm) suggested underlying insulin resistance. Gravidity, parity, and miscarriage analysis revealed 69.2% nulligravida, 78.2% nullipara, and 7.8% miscarriage among the studied patients. The thyroid gland examination indicated that 70.4% had a normal appearance, 10.4% had a diffuse goiter, 16.4% had a multi-nodular goiter, and 2.8% had a solitary thyroid nodule. Functional assessment revealed 69.6% euthyroid, 14.8% with subclinical hypothyroidism, 9.6% hypothyroid, 4.8% hyperthyroid, and 1.2% subclinical hyperthyroidism. Thyroid-stimulating hormone (TSH) levels correlated significantly with body weight, BMI, and miscarriage in PCOS patients (P-value <0.001, <0.001, and 0.012, respectively).

Conclusion: This study underscores the connection between thyroid abnormalities and reproductive parameters in PCOS.

Keywords

Thyroid Hormonal Abnormalities; Polycystic Ovary Syndrome; Egyptian Females

Subject Area

Internal Medicine

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