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Corresponding Author

Abdelrahman M. Mohammed

Document Type

Original Article

Abstract

Background: Obesity has become a serious public health problem globally. Non-alcoholic pancreatic lipomatosis is characterized by pancreatic fat infiltration or pancreatic islet steatosis resulting in abnormal adipokine secretion, insulin resistance, impaired βcell function, and decreased insulin secretion.

Aim: To assess the relationship between non-alcoholic fatty pancreatic disease and type 2 diabetes mellitus among Egyptian patients.

Methods: We enrolled 80 type 2 diabetic patients along with 80 healthy control individuals, all were assessed by abdominal ultrasound and CT scan to determine the degree of pancreatic steatosis based on echogenicity of pancreatic tissue, and four-scale grading system as the visual assessment criteria for pancreatic fat deposition using CT images.

Results: We found that the diabetic group demonstrated a prevalence of fatty pancreas accounting for 43.8% versus 7.5% in the healthy control group with a p-value <0.001. BMI, ALT, AST, amylase, lipase, ALT, AST, cholesterol, LDL, TG, and HbA1c were positively correlated with the degree of fatty pancreas. BMI, TG, and LDL levels are independent predictors for fatty pancreas after adjusting for other risk factors such as cholesterol level, HDL, and HBA1c with p values <0.01. BMI, ALT, AST, Hb A1c, and lipid profile can significantly predict a fatty pancreas.

Conclusion: Pancreatic steatosis is significantly associated with type 2 diabetes, glycemic control, lipid profile, and body mass index. The degree of non-alcoholic pancreatic lipomatosis by CT scan significantly correlates with body mass index, lipid profile, and glycemic control.

Keywords

Non-alcoholic pancreatic lipomatosis, type 2 diabetes, obesity

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