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Corresponding Author

Mohamed El-Sayed Mohamed Khalil

Document Type

Original Article

Abstract

Background: Interactions between thyroid hormones and renal function are complex. Both the metabolism and disposal of thyroid hormones include the kidney. Additionally, it plays a crucial role in the function of thyroid hormones.

Objectives: To assess thyroid hormone disorders in advanced chronic kidney disease.

Patients and methods: This cross-sectional study involved fifty chronic kidney disease patients as group I and 50 end-stage renal disease patients as group II. It was performed in the Internal Medicine Department and Nephrology Unit of El-Hussein Hospital, Al-Azhar University. Glomerular filtration rate (GFR) was calculated using the Modification of Diet in Renal Disease study (MDRD) equation. Free triiodothyronine (FT3), free thyroxine (FT4), and thyroid stimulating hormone (TSH) were measured.

Results: 24% and 1% of ESRD patients had subclinical hypothyroidism and overt hyperthyroidism, respectively. At the same time, 4% of CKD group patients had subclinical hyperthyroidism. Free triiodothyronine and free thyroxine were significantly positively correlated with GFR, while thyroid stimulating hormone was significantly negatively correlated with GFR.

Conclusion: Both free triiodothyronine and free thyroxine levels were significantly reduced among ESRD patients and significantly correlated with GFR.

Keywords

CKD; ESRD; thyroid disorders

Subject Area

Internal Medicine

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