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Corresponding Author

Mahmoud Mohammed Mohammed Elmoazamy

Document Type

Original Article

Abstract

Background: A chronic autoimmune disorder that can impact any organ or tissue, systemic lupus erythematosus (SLE) is a global condition. A disease involves the interaction of hormonal fluctuations, environmental triggers, and genetic predisposition.

Aim and objectives: To determine the relationship between urinary sCD25 and lupus nephritis (LN) activity.

Subjects and methods: Prospective research was done on 60 cases ( 57 female and three male ) and 25 adult persons (20 female and five male) as a control group. This study was done in Al-Azhar University Hospital Asyut's nephrology unit and Elhussin Universal Hospital's nephrology unit, with informed written consent from all participants.

Results: Regarding symptoms, all controls had no chronic disease. Asthma, cardiac diseases, DM, and HTN were observed in 8 (13.33%), 3 (5%), 12 (20%), and 10 (16.67%) cases group, respectively. There was a significant increase in DM and HTN observation in the cases group. All case groups were managed with steroids. Also, in the cases group, 8 (13.33%), 13 (21.67%), and 16 (26.67%) were managed with Azathioprine, Cyclophosphamide, and Hydroxychloroquine, respectively. No medicine was recorded in the control group. There was a significant positive association among WBCs, Urea, Creatinine, ESR 1st h, ESR 2nd h, UP/Creatinine ratio, C3, C4, and CD25.

Conclusion: Urinary CD25 349.5 is a useful noninvasive biomarker for examining renal disease affection in cases with LN since it is strongly associated with various laboratory and clinical markers.

Keywords

Lupus Nephritis; Urinary sCD25; renal dysfuction

Subject Area

Internal Medicine

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