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Corresponding Author

Mohamed Saad Ahmed ElMalla

Document Type

Original Article

Abstract

Background: Deterioration of renal function over hours, days, or weeks is referred to as Acute Kidney injury (AKI). Albumin & Neutrophils have been demonstrated to give more details regarding the outlook for acute kidney injury as markers of inflammatory and immunological responses.

Aim and objectives: To determine the Role of Neutrophil Percentage to Serum Albumin ratio (NPAR) as a prognostic indicator for developing Acute Kidney injury in critically ill cases.

Patient & methods: A total of sixty individuals were included in this prospective study, with thirty participants in Group A having blood albumin levels below 3.5 g/dl and 30 people in Group B having levels above 3.5 g/dl. The study was carried out at the Intensive Care Unit at Damanhur Educational Hospital.

Results: With a cutoff value 16.4, NPAR showed a significant association with death occurrence, with sensitivity reaching (75%) and specificity of (77%). NPAR level in the cases that died was significantly higher than that of those who recovered (p under 0.0001), indicating a statistically significant difference. There was substantial negative association amongst NPAR & serum albumin, systolic blood pressure (SBP), haemoglobin (Hgb), diastolic blood pressure (DBP), platelet (Plt) & estimated glomerular filtration rate (e GFR) while there was significant positive correlation amongst Neutrophil Percentage to Serum Albumin ratio in addition to age, white blood cells (WBC) count, C-reactive protein (CRP), neutrophil percentage and creatinine level.

Conclusion: Higher NPARs were related with severity & mortality among critically ill patients with AKI, and NPAR can be used as a prognostic marker with high accuracy.

Keywords

AKI; NPAR; Critically ill Patients

Subject Area

Internal Medicine

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