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Corresponding Author

Abdalwahab Mohamed Aliser

Document Type

Original Article

Abstract

Background: Glaucoma is clinically defined as progressive optic neuropathy due to an intra-ocular pressure that is sufficiently high to be intolerable for ocular neural tissue. This pressure interferes with proper oxygenation, leading to the loss of the cells that line the retina.

Objective: Assessing the relation between the peaks of intraocular pressure measurement taken while drinking water test and the changes in spectral domain optical coherence tomography (SD-OCT) in pre-perimetric glaucomatous (PPG) eyes.

Patients and methods: A prospective study included cases attending the outpatient clinic at Cairo Fatemic Hospital from October 2019 till March 2021. The study included 50 subjects aged over 35, with minimum best corrected visual acuity of 0.8, with an open angle of the anterior chamber, explicit ocular media, and matched glaucoma suspect criteria. The study correlated the mean IOP changes after the Water Drinking Test (WDT) and OCT parameters for the optic nerve head (ONH) & retinal nerve fibre layer (RNFL).

Results: The alterations in intraocular pressure following the Water Drinking Test were positively correlated with the vertical cup/disc ratio (VCDR). When looking at intraocular pressure changes following WDT about retinal nerve fibre layer thickness, rim area, & disc area, a strong negative connection was seen.

Conclusion: WDT in PPG patients showed significant correlations with structural OCT parameters and can be considered for detecting patients at risk for disease progression.

Keywords

Intra Ocular Pressure; Water Drinking Test; Optical Coherence Tomography; Pre-perimetric Primary Open Angle Glaucoma

Subject Area

Ophthalmology

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