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Corresponding Author

Ramy Mohamed Abd-Elhady

Document Type

Original Article

Abstract

Background: Diabetes mellitus is the most prevalent metabolic condition. Increased galectin-3 plasma concentrations have been linked to micro- and macro-vascular problems of Type-2 diabetes mellitus (T2DM).

Aim and objectives: To study the correlation between serum concentrations of galectin 3 in prediabetic and type 2 diabetic individuals with macro and microvascular complications.

Patients and Methods: This case-control research was performed on 160 cases and 40 healthy controls. Cases are separated into five groups: Group (A): 40 prediabetic patients, Group (B): 40 individuals with T2DM without complications, Group (C): 40 individuals with T2DM with microvascular complications, Group (D): 40 individuals with T2DM with macrovascular complications and control Group: 40 healthy controlled attended in outpatient's clinics at AL- Azhar university hospitals from July 2022 to April 2023.

Results: Our finding indicated that there was a significant increase in plasma level of galectin -3 in group A, group B, group C, and group D when contrasted with healthy control group. There was a significant distinction between group A and group B concerning Homeostatic Model Assessment for Insulin Resistance (HOMA-IR), hemoglobin A1c (HbA1C), Triglycerides, low-density lipoprotein cholesterol (LDL-C), High-density lipoprotein cholesterol (HDL-C), galectin-3 and between group C and group D concerning HbA1C, HDL-C & Galectin-3.

Conclusion: One potential biomarker for the early detection of diabetes and prediabetes is galectin-3. Additionally, it can measure how diabetic microvascular and macrovascular problems are developing. Galectin-3 levels were higher in instances with type 2 diabetes compared to non-diabetic individuals, according to our findings.

Keywords

Hemoglobin A1c, Galectin-3, Type-2 diabetes mellitus

Subject Area

Internal Medicine

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