Document Type
Original Article
Abstract
Background: Recent data found an increased risk of insulin resistance (IR) and Helicobacter pylori (HP) infection in HP-positive individuals regardless of whether they have diabetes.
Objective: To explore the potential role of HP in increasing IR in diabetic and nondiabetic subjects.
Patients and Methods: Of the eighty participants in the trial, 40 had type 2 diabetes (T2DM), and the other 40 were nondiabetics. An upper endoscope diagnosed HP infection, a biopsy was obtained, histopathology was examined, and a stool antigen test was done. Insulin resistance was diagnosed using the Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) method. All patients were collected from Al-Hussien University Hospital – Internal Medicine Department in Cairo. Egypt.
Results: Out of the 40 individuals with (T2DM), 30 had IR, and 10 did not. There were a total of 80 patients in the group. HP infection was substantially more common in IR patients than Non-IR patients (93.3% versus 60%, p-value = 0.011), as verified by stool antigen and histopathology. However, of the remaining 40 nondiabetic individuals, 16 had IR, and 24 did not; moreover, IR patients had a considerably greater rate of HP infection than non-IR patients (100% versus 75%, p-value = 0.030).
Conclusion: This study indicates a significant relationship between HP infection and IR in diabetic and nondiabetic populations.
Keywords
Helicobacter pylori; Insulin resistance; type 2 diabetes mellitus
Subject Area
Internal Medicine
How to Cite This Article
Kuwairi, Hussin Mohammed Saleh; Hemida, Mahmoud Haddad; Abdelaleem, Sadek Mostafa Sadek; Tealeb, Al Sayed Mohamad; and byomy, Marwa Ahmed
(2024)
"Helicobacter pylori Infection and Insulin Resistance in Diabetic and Nondiabetic Subjects,"
Al-Azhar International Medical Journal: Vol. 5:
Iss.
4, Article 43.
DOI: https://doi.org/10.58675/2682-339X.2387
