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Corresponding Author

Kamel Akram El-Shorbgy

Document Type

Original Article

Abstract

Background: IBD, which includes both Crohn's disease (CD) and ulcerative colitis (UC), is a chronic, intermittent inflammatory bowel illness that relapses frequently. A noninvasive indicator of gut inflammation, calc granulin-C (S100A12) has been found to be high in a number of chronic inflammatory conditions, including rheumatoid arthritis, cystic fibrosis, and, more recently, inflammatory bowel disease (IBD).

Aim and Objective: To assess the efficacy of serum S100A12 as a diagnostic and follow-up marker in Egyptian children suffering from inflammatory bowel disease (IBD).

Patients and methods: This study was carried out on 60 children classified into three groups: chronic disease group in remission (n=20), newly diagnosed group (n=20), and control group (n=20). The following was done for all patients: detailed history, complete general examination, local abdominal examination, examination of other systems, and endoscopy findings. Serum S100A12 level Enzyme-linked Immunosorbent Assay Kit was used for quantification.

Results: Our study found statistically noteworthy increased mean values of CRP and ESR in the newly diagnosed group compared to the chronic disease group. Our study showed highly statistically noteworthy increased mean values of Serum S100A12 in the Newly diagnosed group, followed by the chronic disease group, and the lowest value in the control group. There was a statistically significant positive correlation between fecal calprotectin and Serum S100A12 in the group with chronic disease cases and newly diagnosed cases.

Conclusion: Serum s100A12 may be included in the diagnosis of IBD.

Keywords

Inflammatory bowel diseases; Ulcerative colitis; Crohn's disease; S100A12; Calgranulin C

Subject Area

Pediatrics & its Subspecialty.

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