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Document Type

Original Article

Abstract

Background: Glaucoma is a prevalent ocular disorder characterized by progressive damage to the optic nerve, leading to irreversible vision loss if left untreated. Aim: This research aims to evaluate the quantity and quality of the precorneal tear film in primary open angle glaucoma studied cases who are using topical prostaglandin analogues (PGAs), by conducting Schirmer and break-up time tests. Methods: It was a prospective case-control clinical trial that involves 120 eyes, divided into two groups. The first group consists of 30 age-matched healthy individuals, while the second group comprises 30 patients who are diagnosed with primary open angle glaucoma (POAG) & are under control with topical prostaglandin analogues attending the ophthalmology department at AL-Azhar university hospitals. Glaucoma patients under prostaglandin analogues are subdivided into three subgroups based on the duration of drug intake: early (1 month), 3months, & six months. Results: The BUT test outcomes indicate significant variation between the two groups, with Group 1 (control) having a mean BUT of 17.67 seconds and Group 2 (patients) having a significantly lower mean BUT of 4.1 seconds. Group 2 had also a significantly lower mean Schirmer test value of 8.43±3.75, suggesting reduced tear production in these individuals. Conclusion: Overall, the data suggests that primary open angle Glaucoma under prostaglandin analougues has significant effects on various aspects of eye health, including intra ocular pressure (IOP), cup to disc (C/D) ratio, tear film stability, and tear production.

Keywords

prostaglandin analogues; antiglaucoma medication; precorneal tear film.

Subject Area

Ophthalmology

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