Document Type

Original Article


Background: Abortion is a minor complication of pregnancy, defined as the spontaneous loss of the fetus, which occurs in 15-20% of pregnant women. Recurrent miscarriages, which occur in approximately 1% of women of childbearing age and are defined as miscarriages of two or more pregnancies in consecutive pregnancies. Aim: To determine the association between subclinical hypothyroidism in pregnant women and recurrent miscarriage. Patients and Methods: This observational study was conducted in December 2021 and May 2022 on nine pregnant women at Assiut University's Al-Azhar Hospital. Patient groups who complained of recurrent miscarriage (at least two unexplained recurrent miscarriages) and control groups included pregnant women who had previously given birth to at least one child. Result: Statistically significant differences between the two groups studied (case and control). The mean miscarriage rate in the case groups was range from 2.0 to 7.0. The mean factor in the control group was range from 1.0 to 7.0. The calculation was entered as statistically significant for the studied groups (cases and controls) with respect to FT4, thyroid status, cholesterol, triglycerides, creatinine, urine, ALT, AST and albumin. It appears that there were not enough combinations (cases and controls) of FT3 and TSH syntax to be statistically significant. Statistics show that the number of combinations (tilde and control) without anti-TPO syntax has a significant impact. Conclusion: There is a weak association between subclinical hypothyroidism and recurrent spontaneous abortion in pregnant women.


Subclinical Hypothyroidism; miscarriage; pregnant; Reccurent

Subject Area

Internal Medicine