Document Type
Original Article
Abstract
Background: The eye disorder known as diabetes-related macular edema (DME) is frequent and dangerous. DME is one of the easiest conditions to treat even though it can cause vision impairment. Photocoagulation, intravitreal medicines, in addition to surgical excision are some of the therapy options that are currently available. Aim of the work: to evaluate how intravitreal Ranibizumab injections affected corneal endothelial changes over the course of 3 months in patients diagnosed with DME. Patients and Methodology: A case-control study at Giza Memorial Institute of Ophthalmic Research from May 2022 till Nov 2022. compared patients with DM who have good glycemic control and patients who have poor glycemic control with macular edema. Ten eyes received 0.5 mg/0.05 ml ranibizumab intravitreal injections for three consecutive months, specular microscopy for endothelial cell number and thickness of the cornea determination was done prior to administration and after this. Three groups were divided into: Group 1: Ten eyes of Diabetic patients (type and accompanying non-proliferative diabetic retinopathy and are going to undergo intravitreal injection of ranibizumab. Group 2: Ten eyes of diabetic patients without diabetic retinopathy. Group 3: Ten eyes of healthy adults of the same age group. Results: Our research revealed that whereas endothelial cell hexagonality (HEX%), coefficient of variation (CV), as well as the central corneal thickness (CCT), did not differ between diabetes mellitus (DM) patients and controls, DM patients proved to have lower endothelial cell density (ECD) than healthy participants of identical gender and age. Conclusion: injection of anti-vascular endothelial growth factor (Anti-VEGF) Intravitreally in DME patients showed no corneal endothelium or CCT changes after receiving ranibizumab 0.5 mg/0.05 ml. Therefore, the safety of intravitreal anti-VEGF injections has been determined for the corneal endothelium. extra researches are needed.
Keywords
Diabetes; Ophthalmolgist; Macular odema; Lucentis; Ranibizumab
Subject Area
Ophthalmology
How to Cite This Article
Elarabi, Ahmed Mahmoud Ahmed; Eid, Mohamed Zakaria; and Abdelkawy, Hatem Mahmoud Samy
(2024)
"Specular Microscopic Evaluation Of Corneal Endothelium After Intravitreal Injection Of Ranibizumab For Treatment Of Diabetic Macular Edema,"
Al-Azhar International Medical Journal: Vol. 5:
Iss.
2, Article 12.
DOI: https://doi.org/10.58675/2682-339X.2278
