Abstract
Background: Vitamin D deficiency is more common in children with systemic lupus erythematosus (SLE) than those without the illness , this could be because of disease activity and corticosteroid therapy.
Objectives: This research set out to determine the status of 25-hydroxyvitamin D (VitD3) in juvenile systemic lupus erythematosus and how it relates to disease activity, pharmacological treatments, and other variables.
Patients and Methods: 32 children with juvenile systemic lupus erythematosus (JSLE) and 29 healthy controls made up the two groups of children that were the subject of the study. Disease activity was assessed using the modified Systemic Lupus Erythematosus Disease Activity Index 2000. A direct and competitive electrochemiluminescence immunoassay was employed to quantify serum levels of 25-hydroxyvitamin D.
Results: SLEDAI-2K was 6.5 ± 3.3, and the average serum 25 OH Vit-D level was 19.28 ± 7.5 ng/mL. Vitamin D3 levels were elevated in patients with SLEDAI-2K< 4 compared to those with SLEDAI-2K ≥4 (23.1 ± 6.5 vs. 15.2 ± 4.7, p = 0.001). VitD3 levels were substantially lower, and SLEDAI-2K was higher in patients who used systemic corticosteroids (SCS) than in those who did not. Furthermore, Vitamin D3 levels exhibited an inverse relationship with disease activity (r = -0.558, p = 0.001) and steroid doses (r = -0.491, p = 0.005).
Conclusion: VitD3 deficiency is prevalent among JSLE patients. Additionally, SLEDAI-2K and SCS dosage have an inverse correlation with serum VitD3 levels. According to these findings, vitamin D deficiency may predict disease activity and can influence flare-ups in children with JSLE.
Article Type
Original Article
Keywords
Vitamin D; Juvenile systemic lupus erythematosus; disease activity
Subject Area
Rheumatology and Medical Rehabilitation
How to Cite This Article
Kandeel, Sherif Ahmed Samy and Yossef, Badawy W. Abo-Bakr
(2025)
"The Importance of Monitoring 25 Hydroxy Vitamin D Level among children with Juvenile systemic lupus erythematosus,"
Al-Azhar International Medical Journal: Vol. 5:
Iss.
12, Article 54.
DOI: https://doi.org/10.58675/2682-339X.2833
