Abstract
Background: Nonalcoholic fatty liver disease (NAFLD) one of principalreasons of cirrhosis and hepatocellular carcinoma (HCC), it impacts a minimum of 25% of the adult population worldwide. During active phase of HBV infection, patients who have previously contracted the virus may encounter liver damage. Additionally, HBV DNA incorporation into host genome may elevate likelihood of HCC.
Aim: Detect the connection between NAFLD severity and prior HBV infection.
Methods: This cross-sectional research was executed on 50 metabolic dysfunction–associated fatty liver diseas (MAFLD) patients, two groups of subjects were formed: Group A: 40 negative Anti-HBc patients and group B: 10 positive Anti-HBc patients.
Results: The fibrosis-4 (FIB-4) scores, indicative of liver fibrosis, are significantly greater in Group B, with a mean score of 2.97 compared to 0.98 in Group A. The Fibroscan results reinforce the presence of more advanced fibrosis in Group B, where a higher proportion of patients exhibit stages F2 and F3 fibrosis compared to Group A. Specifically, Group B has a larger percentage of patients with higher degrees of fibrosis, including stages F3. In multivariate analysis, positive Anti-HBc status remained a significant predictor of high-grade fibrosis.
Conclusions: Positive Anti-HBc status stayed a significant predictor of high-grade fibrosis. MAFLD patients who had positive anti-HBc have a greater probability of having severe fibrosis than those who had negative anti-HBc.
Article Type
Original Article
Keywords
HBV Infection; Severity; Nonalcoholic Fatty Liver Disease; Fibrosis-4
Subject Area
Internal Medicine
How to Cite This Article
Abdelrazek, Fathy Ghamry; Abdel Baki, Amin Mohamed; Abdellatif, Salama saad; Eliwa, Ahmed Maher; and Elgendar, Mohammed Salah Eldin Mohammed
(2024)
"The Impact of Previous HBV Infection on The Severity of Nonalcoholic Fatty Liver Disease,"
Al-Azhar International Medical Journal: Vol. 5:
Iss.
12, Article 50.
DOI: https://doi.org/10.58675/2682-339X.2829
