Role of Serum Bicarbonate and Lactate as a Predictor of Mortality in Critically Ill Patient with Sepsis

Authors

Amani Kamal Ali, Internal Medicine, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt
Seham Sabry Qutb, Internal Medicine, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt
Sara Younes Abdelaziz, Clinical Pathology, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt
Nada Mohamed Abd El Fatah, Internal Medicine, Faculty of Medicine for Girls, Al-Azhar University, Cairo, EgyptFollow

Corresponding Author

Nada Mohamed Abd El Fatah

Abstract

Background: Sepsis is a severe condition described by organ dysfunction due to infection and an abnormal host response, Aim: To assess the role of serum bicarbonate and lactate as a predictor of mortality in critically ill case with sepsis.

Patients and methods: This prospective investigation has been performed on 80 critically-ill cases with sepsis have been divided into: Group I: (40 patient have sepsis with chronic illness) and Group II: (40 patient have sepsis without chronic illness) admitted to intensive care unit in AI Zahraa University Hospital from April 2023 to May 2024.

Results: A statistically significant positive association was detected among bicarbonate (HCO3) and hematocrit test (HCT), PH and carbon dioxide (Co2), also statistically significant negative association among potassium (K) and HCO3 and statistically significant positive association among HR and lactate and total bilirubin in group one while in group two there was a statistically significant negative correlation among HCO3 and partial pressure of oxygen (PaO2), SOFA score, APACHE II score, lactate, urea and creatinine. Also, statistically significant positive association between HCO3 and PH and CO2 and a statistically significant positive correlation between lactate and SOFA score and PACHE II score.

Conclusion: Serum lactate is the most accurate predictor of mortality in sepsis due to its strong association with SOFA score. Bicarbonate serum is also a good predictor of sepsis clinical outcomes, and low levels of bicarbonate negatively correlate with serum lactate, increasing morbidity and mortality in critically ill cases.

Article Type

Original Article

Keywords

Sepsis; bicarbonate; lactate; critically ill patients

How to Cite This Article

Ali, Amani Kamal; Qutb, Seham Sabry; Abdelaziz, Sara Younes; and Abd El Fatah, Nada Mohamed (2024) "Role of Serum Bicarbonate and Lactate as a Predictor of Mortality in Critically Ill Patient with Sepsis," Al-Azhar International Medical Journal: Vol. 5: Iss. 12, Article 31.
DOI: https://doi.org/10.58675/2682-339X.2810