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Corresponding Author

Eman Mohamed El-Sayed Ahmed Yousef

Document Type

Original Article

Abstract

Background: The main problem in clinical nephrology is the persistent and gradual rise in the number of people worldwide who suffer from end-stage renal disease (ESRD). The effect of DR on the growing population with chronic kidney disease (CKD) and end-stage renal disease is significant.

Aim: To investigate the role of Angiopoietin-1 as an early biomarker of diabetic nephropathy.

Patients and methods: This investigation was a cross-sectional investigation conducted on 90 participants,60 cases with type 2 diabetes more than 18 years old selected from the internal medicine department of the Al-Zahraa University Hospital, thirty healthy subjects age sex matched as a control group from March 2023 till October 2023.

Results: There was statistically significantly higher angiopoietin-1 in those with micro and healthy control groups than in patients with macro-albuminuria. Also, there was statistically significantly higher angiopoietin-1 in those cases with micro than macro-albuminuria. At a cut-off point <280.2, serum angioipiotien-1 level has 93.1% sensitivity and 72.4% specificity for the prediction of macro-albuminuria. At a cut-off point <333.9, serum angioipiotien-1 level has 75.9% sensitivity and 63.3% specificity for prediction of micro-albuminuria.

Conclusion: ANGPT1 could potentially serve as the early biomarker for the progression of renal impairment associated with diabetes as it has a statistically significant negative correlation with age, blood glucose, HbA1C, cholesterol, triglyceride, serum albumin, serum urea, urinary creatinine, albumin creatinine.

Keywords

Angiopoietin-1; diabetic nephropathy; macro-albuminuria; microalbuminuria

Subject Area

Internal Medicine

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