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Corresponding Author

Mohamed Mahmoud Mohamed

Authors ORCID

Role of L- Carnitine as Adjuvant Therapy with Letrozole for Ovulation Induction in Women with Polycystic Ovarian Syndrome (PCOS)

Document Type

Original Article

Abstract

Background: Polycystic Ovarian Syndrome (PCOS) is a frequent endocrine disorder that impacts females who are in their reproductive years. There was a correlation between this syndrome and the presence of bigger and more dysfunctional ovaries, higher. L-carnitine has the potential to enhance ovarian function and boost the risk of a successful pregnancy.

Aim of the work: To evaluate the effect of adding LC with letrozole on inducing ovulation in females with polycystic ovary syndrome, we examined changes in endometrial thickness, ovulation rate, and clinical and chemical pregnancy.

Patients and Methods: blinded randomized controlled investigation, whereas two hundred females with polycystic ovarian syndrome diagnosed according to Rotterdam criteria (2003) were shared and equally distributed to double groups, each group involving one hundred females. The first group added L-carnitine to letrozole, while the second group took letrozole alone with an evaluation of ovulation induction.

Results: The accumulated ovulation rate was statistically significantly higher in the first group than in the second group. Also, the accumulated chemical and clinical pregnancy rates were greater in the first group than in the second group. The endometrial thickness was statistically significantly reduced in the participants of the first group compared to the participants of the second group.

Conclusions: The evaluated variables of the research results demonstrated that adding L-carnitine to letrozole throughout ovulation induction in polycystic ovarian syndrome patients improved the endometrial thickness, ovulation rate, and clinical and chemical pregnancy rates.

Keywords

L-carnitine; Letrozole; Ovulation Rate; Chemical & Clinical pregnancy; Endometrial Thickness; PCOS

Subject Area

Obstetrics and Gynecology

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