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Corresponding Author

Ahmed Abdallah Ali

Document Type

Original Article

Abstract

Background: Non-alcoholic fatty liver disease (NAFLD) is a leading metabolic disorder that commonly progresses to non-alcoholic steatohepatitis (NASH), potentially complicated with cirrhosis, liver failure, and hepatocellular carcinoma.

Aim: To compare obeticholic acid (OCA) vs. vitamin E on serum aminotransferases and fibrosis in non-diabetic adults with NASH.

Methods: In the current open-label, randomized, active-controlled study, 150 non-diabetic adults with NASH were randomized into three groups: Group A received OCA (10 mg daily, N=50) plus lifestyle modification, Group B received vitamin E (800 mg daily, N=50) with lifestyle modification, and Group C underwent only lifestyle modification (N=50). The intervention period was 18 months.

Results: The pharmacotherapy groups showed significantly greater reductions in alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels in comparison to the control group (P

Conclusions: In non-diabetic adults with NASH, vitamin E improved biochemical markers and inflammatory parameters but did not significantly improve fibrosis. OCA 10 mg daily dose improved liver stiffness after 18 months of treatment, but with negative effects on lipid profile compared to other study arms.

Keywords

NAFLD; NASH; obeticholic acid; vitamin E

Subject Area

Endemic diseases and tropical medicine

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