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Document Type

Original Article

Abstract

Background: Sepsis syndrome arises from disrupted host responses to infection, causing multiple organs dysfunction. The kidneys are susceptible to sepsis-induced acute kidney injury, leading to extended hospital stays, hindered renal recovery, heightened morbidity & mortality. Aim and objectives: to estimate the diagnostic performance and clinical implications of estimating urinary tissue inhibitor of metaloprotinase-2 (UTIMP-2) in Determining acute kidney injury (AKI) in individuals with sepsis. Subject and Techniques: This case-control study involved 60 adult cases admitted to the Medical Intensive Care Unit (MICU) of the Internal Medicine department at Al Hussein University hospital in the period from January 2022 to July 2022 with AKI as well as another 30 healthy subjects as the control group (group III). participants were separated into 2 equal groups in accordance the presence (group I) or absence of sepsis (group II) after at least 48 hours of hospitalization. Results: Comparison among the three examined groups revealed a statistically significant rise in UTIMP-2 levels in both groups I &II contrasted with group III however comparing group I vs. II regarding UTIMP-2 levels didn’t demonstrate a significant difference. According to the ROC curves, UTIMP-2 ≥ 25 ng/ml, had a sensitivity of 91.67%, specificity of 90% in predicting the incidence of AKI. there was lack of significant correlation between UTIMP-2 and various parameters indicating overall prognostic outcomes in MICU hospitalization. Conclusion: UTIMP-2 estimation in critically ill patients showed good AKI detection ability but had limitations in predicting sepsis-related AKI prognosis and differentiating it from other types of AKI in this population.

Keywords

Sepsis, Acute kidney injury, Metalloproteinase-2, Sepsis-related Acute Kidney Injury.

Subject Area

Internal Medicine

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