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Document Type

Original Article

Abstract

Background: Cardiac magnetic resonance imaging (CMRI) mapping is a novel technique that allows for the measurement of myocardial T1 and T2 values, which reflect its intrinsic tissue properties. Patients and Methods: In 10 healthy individuals and 15 patients with coronary artery disease (CAD), T1 and T2 mapping values were measured on 16 segments of each case at rest and stress. Also, T1 and T2 reactivity, such as the variations in T1 and T2 at rest and post-stress values, were calculated. Results: After stress, native T1 was elevated in healthy individuals and ischemic patients. A statistically significant difference was found (p = 0.005) in T1 reactivity, with the median being 3.847% in the control and 3.539% in the cases. In recovery, the T1 values decreased in both groups, yet the median T1 recovery in control was 1002.6 ms compared to 1016.7 ms in cases, which was statistically significant (p = 0.001). The best T1 reactivity cutoff value for predicting flow-limiting stenosis was 1.17%; it had a specificity of 94.37%, a sensitivity of 66.25%, an NPV of 84.80%, a PPV of 85.50%, and an excellent area under the curve of 0.763 with statistical significance (p = 0.001). Data conclusion: Adding T1 mapping to the dobutamine stress CMR study can increase exam sensitivity and specificity to detect ischemia using T1 reactivity and T1 recovery values.

Keywords

T1 Map; Dobutamine Stress; T1 Stress; Assessment of Ischemia; Non-Contrast CMR; Significant CAD

Subject Area

Cardiovascular

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