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Document Type

Original Article

Abstract

Background: Obesity affects both children and adults and is a major burden on world health. Focusing on childhood obesity is crucial to preventing its problems and further development as adults. Around the world, the prevalence of this nutritional condition among children has risen to alarming levels. Aim and objectives: to evaluate IL6 as a predictive inflammatory cytokine and its relation to BMI and lipid profile, in obese and over-weight children identifying those more like to develop further complication, also to assess the correlation between highly sensitive C -Reactive protein as an inflammatory marker and obesity. And to evaluate the usability of NLR and PLR in detection of subclinical inflammation in obese children. Patients and Methods: Case-control study best describes this research. Ninety kids participated in the study, their ages ranged from (6-12) year, males and females. The study was carried on outpatient and inpatient at Pediatric department at Al-Zahraa University Hospital. Results: Among the groups that were compared, there was a discernable dissimilarity in anthropometric measurements, triceps skin fold thickness, Correlation between BMI and (PLR, NLR, IL-6 and HS-CRP) and Hb A1C and lipid profile except LDL. Conclusion: Children who are overweight or obese tend to have higher neutrophil-to-lymphocyte (NLR) and platelet-to-lymphocyte (PLR) ratios than children who are a healthy weight. Children who are overweight or obese have higher levels of inflammatory mediators including hs-CRP and IL-6 compared to a healthy control group.

Keywords

Inflammatory Markers; Obese Children; NLR; PLR.

Subject Area

Pediatrics & its Subspecialty.

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