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Document Type

Original Article

Abstract

Background: One of the leading causes of death and suffering in the 21st century is chronic kidney disease (CKD). Due to the rise in risk factors like obesity and diabetes, as well as the rising number of people affected with CKD, our study aimed to study the effect of using low-flux in comparison to high-flux dialyzers on serum IL-6 levels in patients undergoing regular hemodialysis (HD).

Patients and Methods: Our study was a randomized controlled trial. Sixty patients were enrolled: 20 CKD patients, 20 dialysis patients using low- flux, and 20 patients using high-flux polysulfone dialyzers. Dialysis sessions were four hours, three times weekly; the Anticoagulant was Heparin or LMWH.

Results: We found significantly (P = 0.047) higher levels of serum IL-6 in HD patients (2.75 ± 0.50 ng/L) than CKD patients (2.49 ± 0.38 ng/L). We also observed significantly higher IL-6 levels after dialysis (p = 0.010) in the low-flux HD group. It was (2.68 ± 0.36 ng/L) post-dialysis vs. (2.95 ± 0.26 ng/L) pre-dialysis. Finally, we found a statistically insignificant difference (P = 0.491) in IL-6 levels after dialysis in the high-flux HD group. It was (3.02 ± 0.57 ng/L) post-dialysis vs. (2.93 ±0.89 ng/L) pre dialysis;

Conclusion: Patients on haemodialysis had serum Interleukin-6 levels that were considerably greater than those with CKD. After dialysis, there were noticeable increases in serum IL-6, especially when low-flux dialyzers were used. Utilizing high-flux dialyzers revealed a slower rise in IL-6, which may point to improved clearance.

Keywords

Low-flux, High-flux Dialyzers, Interleukin 6, Haemodialysis

Subject Area

Internal Medicine

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