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Document Type

Original Article

Abstract

Background: The condition known as gastroesophageal reflux disease arises when the contents of the stomach result in bothersome symptoms and issues. Matrix metalloproteinases are endopeptidases that may break down extracellular matrix elements. They are crucial for tumour invasion and metastasis. Objective: To correlate the expression of metalloproteinase 9 (MMP-9)in patient with mild and severe gastroesophageal reflux disease in their esophageal samples. Method: cross-sectional investigation Patients with mild and severe GERD had their oesophagus tissue biopsied to assess the expression of MMP-9. Age, sex, diagnosis, smoking, body mass index (BMI), and MMP-9 expression were the included variables. Descriptive statistics were used, including the X2 and Kappa tests for diagnosis concordance. Results: There were 50 patients, with 27 (54%) men and 23 (46%) women, with an average age of 55.6 14.75. 19 people (38%) smoke. The average BMI ranged from 20 to 31; 12 (24%) people had obesity. For histological diagnosis, the interobserver concordance was 1.0, and for the severity of esophagitis, it was 0.84. There were 16 patients (32%) with Barrett's oesophagus, 30 (60%) with mild to moderate esophagitis, and 4 (8%) with esophageal cancer. Patients with mild esophagitis (3.4±7.78), moderate esophagitis (12.2±5.23), Barrett's oesophagus (25.7±2.8), and esophageal cancer (38.6±5.26) all had MMP-9 expression.

Smoking and histological diagnosis showed statistically significant correlations with MMP-9 expression.

. Conclusions: Expression MMP-9 showed significant positive correlation with severity of GERD.

Keywords

biopsy, esophageal, gastroesophageal, metalloproteinase-9, reflux

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