Document Type

Original Article


Background: Corneal biomechanics has become an interesting material for the research and progress in modern ophthalmology due to its many uses .In the glaucoma field, biomechanically corrected IOP was measured .Also,in pre-operative assessment in refractive surgery ,KC and CXL.

Corvis ST is a dynamic Scheimpflug technology measures in details the cornea's biomechanical reaction to an air pulse. Intravitreal anti VEGF treatment causes decrease of VEGF levels and shift of CTGF /VEGF balance in favor of CTGF which is present in various tissues as cornea and sclera causing angiofibrotic switch.

Aim of the work : To assess effect of intravitreal injection of ranbizumab (Lucentis) on corneal biomechanics using Corneal Visualization Scheimpflug Technology (Corvis ST).

Patients and Methods: This is aprospective, interventional and non- randomized study included 30 eyes of 30 patients. Before and one month after a three-months treatment of IVI of ranibizumab, Corvis ST parameters were obtained.

Results: Results of the study showed that IOP and bIOP have increased significantly after the injection (P- value 0.03 , 0.04 respectively). Asignificant decrease of CCT after injection was found(P value 0.044). ARTh showed asignificant decrease which correlates with the significant decrease in CBI after injection, which means better corneal biomechanical response

(P values were 0.003, 0.014 respectively).

Conclusion:..In this study intravitreal Ranibizumab injection could change some Corvis ST parameters and other parameters are non statistically different.This suggests assessment of corneal biomechanics using Corvis ST on awide scale.


Corvis ST, Corneal Biomechanics, Ranibizumab, Intravitreal injection.

Subject Area