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Document Type

Original Article

Abstract

Background: Colorectal cancer (CRC) is one of the most serious diseases diagnosed globally. A few research have been conducted to explore the effect of thyroid dysfunction in the progression and danger of CRC. This study aimed to evaluate prevalence of colorectal carcinoma in individuals who have thyroid disorder.

Patients and methods: This was a case control study with (60) persons divided into three groups: Group (I) contained (20) hyperthyroid patients, Group (II) involved (20) hypothyroid patients, and Group (III) included (20) patients with normal thyroid function (control group).

Results: When compared to groups (I) and (III), group (II) had an extremely statistically significant increase in TSH (p-value 0.001). (III). When compared to groups (I) and (III), there was a highly statistically significant rise in serum carcinoembryonic antigen (CEA) in group (II) (III). In comparison to groups (II) and (III), there was a highly statistically significant rise in CA 19-9 in group (III) (I). In compared to groups (III) and (IV), there was a highly statistically significant increase in carbohydrate antigen 125 (CA 125) in group (II) (I). In neither of the groups examined did anyone have an abnormally high CA 125 level. The rate of occurrence of colo-rectal cancer was not significantly different across the groups.

Conclusion: Consistent with the results of the current investigation, both hyperthyroidism and hypothyroidism were associated with a reduced risk of developing CRC.

Keywords

Colorectal cancer; Thyroid dysfunction; Hyperthyroidism; Hypothyroidism

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