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Document Type

Original Article

Abstract

Background: It is possible that environmental allergens and intestinal parasites share antigens that can modulate allergic immune responses. Cross-reactivity studies between common parasitic helminths and house dust mites impacting people is gaining popularity, especially in underdeveloped countries.

Aim of the study: The objective of this study is to study the relation between Ascaris lumbricoids infection with or without treatment on mite sensitization as well as the pathogenic relation between Ascaris and bronchial asthma; if any, and consequent clinical implication on asthma severity.

Subjects and methods: This study comprised of 80 atopic asthmatic patients of moderate severity according to the Global Initiative for Asthma (GINA) guidelines classification in outpatient clinic at Al-Hussein hospital following their free and informed consent. They were classified into two groups: (group A) asthma patients without Ascaris infection and (group B) asthma patients with Ascaris infection. Total IgE, Ascaris antibodies and Specific serum IgE levels to House Dust Mites species Blomia tropicalis (Bt), Dermatophagoides pteronyssinus (Dp), and Dermatophagoides farinae (Df) were measured through enzyme-linked immunosorbent assay (ELISA). Following informed consent for scientific research from the Al-Azhar Ethical Committee for Scientific Research, patients and a control group were enrolled in this study.

Results: The findings revealed that there was statistically significant difference between total IgE in patient with positive Ascaris antibodies and Blomia tropicalis specific IgE.
Conclusion: In conclusion, asthma severity increased in Ascariasis patients associated with Blomia tropicalis.

Keywords

Ascaris lumbricoides; Hosue Dust Mite; Bronchial Asthma

Subject Area

Internal Medicine

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