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Document Type

Original Article

Abstract

Background: A skin depigmentation illness known as vitiligo is brought on by malfunctioning epidermal melanocytes. Cytokines are tiny immune-regulatory chemicals that may cause an unwarranted immunological response. An important immune system regulator is the pleiotropic cytokine IFN-γ.

IFN-γ induces autoantibodies, activates autologous cytotoxic T cells, and causes target cells to undergo apoptosis, all of which support host defense in addition to contributing to autoimmune disease. It is crucial to vitiligo depigmentation induction.

Aim: to measure the IFN-γ concentration in the serum of vitiligo patients and to explain how this level relates to the disease degree and activity.

Methods: This research was cross-sectional and analytical, carried out at dermatology the outpatient clinic of the Suez Canal University Hospitals, Ismailia on 60 participants divided into 2 groups: Patient group: comprised 30 patients who had segmental and non-segmental vitiligo that was stable and active, as determined by the conventional clinical characteristics, and a control group: included 30 healthy people without vitiligo symptoms or indicators were chosen ages and sexes matched to the patients, Results: There is statistical significant statistically relation between IFN-γ concentration and each of VASI and VIDA score activity and the duration of disease, Conclusion; In vitiligo, cytokines control the immune response and depigmentation process. Patients with vitiligo have unbalanced amounts of cytokines. The autoimmune cause of vitiligo involves the expression IFN-γ. In the active stage of vitiligo lesions, the production of the cytokine IFN-γ is connected to the destruction of melanocytes.

Keywords

Vitiligo; IFN-γ; ELISA; Cytokines; Immune response

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