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Corresponding Author

Ahmed O. Ahmed

Document Type

Original Article

Abstract

Purpose: We aim to evaluate and compare the efficacy and safety of Silodosin, Mirabegron, and Tadalafil as a medical expulsive therapy (MET) for lower ureteric stones in adults.

Material and Methods:
A total number of 150 cases who had unilateral single lower ureteric stone between December 2021 and August 2022 were incorporated in this prospective randomized comparative study. The patients were randomly divided into 3 equal groups. The first group received Silodosin medication, the second group received Mirabegron medication, and the third group received Tadalafil medication. The medications would be continued until the expulsion of the stone, for a maximum of 3 weeks. The duration of medical therapy for each patient was no longer than 3 weeks. The treatment duration was until stone expulsion or 3 weeks, whichever came first. The success was considered if the stone passed during 3 weeks of the treatment, if the stone did not pass during the 3 weeks that was considered as a failure and the patient underwent ureteroscopic intervention for stone removal. Results: Altogether 150 patients 50 (33.3%) in group 1 (Silodosin group), 50 (33.3%) in group 2 (Mirabegron group), and 50 (33.3%) in group 3 (Tadalafil group) were enrolled in the study. Expulsion rates for groups 1, 2, and 3 were 86%, 72%, and 78%, respectively, however, no significant difference (p-value > 0.05) was determined.
Conclusion: While none was noticeably better than the others, silodosin, mirabegron, and tadalafil showed increased expulsion rates for distal ureteral stones.

Keywords

(silodosin; mirabegron; tadalafil)

Subject Area

Urology

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