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Document Type

Original Article

Abstract

Background: Cyclophosphamide used commonly in chemotherapy in various types of cancers and also autoimmune diseases. But it had altered histological structures caused by oxidative stress. Cinnamon Oil has an antioxidant plus anti-inflammatory activity. Objective: to determine the histological differentiation in the kidney of adult male albino rats exposed to cyclophosphamide plus role of co-treatment by cinnamon oil. Methods: The study was done at Pharmacology Department Laboratory, Faculty of Medicine, Al-Azhar University between June and October 2022. Twenty-four male adult albino rats divided into 4 groups were involved in our study, each group is formed of six rats. Group I (control group) take normal diet, Group II treated with Cyclophosphamide only, Group III treated with Cinnamon Oil 10 days just after- Cyclophosphamide, Group IV treated with Cinnamon Oil 5 days previous and 5 days later Cyclophosphamide. The kidneys dissected then removed for illustration under light microscope and statistical study. Results: Illustration under light microscope of the renal cortex belong group II showed shrunken glomeruli with widening of Bowman's space and inflammatory interstitial infiltration. There were dilatations in both proximal and distal convoluted tubules. The amount of collagen in glomeruli increased in the interstitial tissue stained by Masson's sections. Examination of group III and IV kidneys showed improvement in histological changes. Conclusion: intake of Cinnamon Oil caused recovery in structure. May reach parameters of the group I, also this improvement much better in group IV than group III.

Keywords

Cinnamon oil; cyclophosphamide; kidney

Subject Area

Anatomy

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